Article abstract, "The application of artificial intelligence (AI) in STEM education (AI-STEM), as an emerging field, is confronted with a challenge of integrating diverse AI techniques and complex educational elements to meet instructional and learning needs. To gain a comprehensive understanding of AI applications in STEM education, this study conducted a systematic review to examine 63 empirical AI-STEM research from 2011 to 2021, grounded upon a general system theory (GST) framework."